An intuitive approach to quantum circuit simulation

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Includes bibliographical references (leaf 27).The study of quantum logic and quantum algorithms is still in its infancy. Quantum algorithms can potentially solve many problems much more efficiently than their classical counterparts, and research in the field is fast-paced and dynamic. The theory that motivates the creation and analyses of quantum algorithms is very complicated and often requires extensive knowledge of advanced mathematics such as complex linear algebra, modular arithmetic, and Fourier analysis. This poses much difficulty for beginners in the field. A student may better understand an algorithm by visualizing each step and observing the state of the system over time. While there are many representations of a quantum algorithm, perhaps the most intuitive is the quantum circuit realization, analogous to the classical Boolean logic circuit. In this representation, the quantum system evolves along a set of quantum "wires" that connect various quantum gates or operators. Few software packages have been written to simulate quantum logic graphically, and most lack a level of user-friendliness beneficial to the beginner. QLS (Quantum Logic Simulator) is designed to simulate basic circuits of up to 20 "quantum bits." The user may add components, simulate circuits, and view various informative outputs using an intuitive, mouse-driven interface. The research goal is divided into two main parts: simulation and user interface. On the simulation side, the simulator is robust enough to handle a wide range of possible logic circuits. This level of generality often pushes the classical computer to its limits due to the natural inefficiency of classical simulation of quantum systems [1]. QLS utilizes a variety of techniques to simulate various circuit components while maintaining generality. On the user-interface side, the simulator is designed to be intuitive, be easy-to-use, and present meaningful outputs that facilitate understanding of quantum algorithms. If successful, QLS may become a helpful teaching aid in introductory quantum logic and algorithms

The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice

International audienceGouty arthritis is caused by the deposition of monosodium urate (MSU) crystals in joints. Despite many treatment options for gout, there is a substantial need for alternative treatments for patients unresponsive to current therapies. Tyrosine kinase inhibitors have demonstrated therapeutic benefit in experimental models of antibody-dependent arthritis and in rheumatoid arthritis in humans, but to date, the potential effects of such inhibitors on gouty arthritis has not been evaluated. Here we demonstrate that treatment with the tyrosine kinase inhibitor imatinib mesylate (imatinib) can suppress inflammation induced by injection of MSU crystals into subcutaneous air pouches or into the ankle joint of wild type mice. Moreover, imatinib treatment also largely abolished the lower levels of inflammation which developed in IL-1R1-/- or KitW-sh/W-sh mice, indicating that this drug can inhibit IL-1-independent pathways, as well as mast cell-independent pathways, contributing to pathology in this model. Imatinib treatment not only prevented ankle swelling and synovial inflammation when administered before MSU crystals but also diminished these features when administrated after the injection of MSU crystals, a therapeutic protocol more closely mimicking the clinical situation in which treatment occurs after the development of an acute gout flare. Finally, we also assessed the efficiency of local intra-articular injections of imatinib-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles in this model of acute gout. Treatment with low doses of this long-acting imatinib:PLGA formulation was able to reduce ankle swelling in a therapeutic protocol. Altogether, these results raise the possibility that tyrosine kinase inhibitors might have utility in the treatment of acute gout in humans

A Real-Time Clinical Endoscopic System for Intraluminal, Multiplexed Imaging of Surface-Enhanced Raman Scattering Nanoparticles

<div><p>The detection of biomarker-targeting surface-enhanced Raman scattering (SERS) nanoparticles (NPs) in the human gastrointestinal tract has the potential to improve early cancer detection; however, a clinically relevant device with rapid Raman-imaging capability has not been described. Here we report the design and <i>in vivo</i> demonstration of a miniature, non-contact, opto-electro-mechanical Raman device as an accessory to clinical endoscopes that can provide multiplexed molecular data via a panel of SERS NPs. This device enables rapid circumferential scanning of topologically complex luminal surfaces of hollow organs (e.g., colon and esophagus) and produces quantitative images of the relative concentrations of SERS NPs that are present. Human and swine studies have demonstrated the speed and simplicity of this technique. This approach also offers unparalleled multiplexing capabilities by simultaneously detecting the unique spectral fingerprints of multiple SERS NPs. Therefore, this new screening strategy has the potential to improve diagnosis and to guide therapy by enabling sensitive quantitative molecular detection of small and otherwise hard-to-detect lesions in the context of white-light endoscopy.</p></div

Real-time, multiplexed imaging overlaid onto 3D lumen topography in a colon phantom.

<p>(a) Top view of the colon phantom. Location of some the SERS samples are shown, some of which were placed directly in front of a fold (S482 and S481). (b) Bottom view of the colon phantom. Location of some the SERS samples are shown, some of which were placed directly in behind a fold (S493, S420, and the Equimolar sample). The Equimolar sample consists of an equal mixture of all 6 flavors. (c) The phantom measured roughly 8cm tall. The laser can be seen sweeping along the lumen of the surface. (d) Both the topography and Raman signal overlay is being generated simultaneously and in real-time. A total of 6,500 pixels (65 rev x 100 pix/rev) were acquired in a period 65 seconds (1 rev/s). See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0123185#pone.0123185.s003" target="_blank">S3 Video</a> for real-time reconstruction and Raman signal overlay.</p

Raman Spectrum of various SERS nanoparticles.

<p>The spectrum shown here are for 6 different SERS nanoparticles types, or flavors: S493, S440, S482, S420, S481, and S421. The only difference in the construction of each flavor is the Raman active layer, which results in unique spectra. The units for the x-axis is given in Raman Shift, which can be calculated as follows: Raman Shift = 1/λ_ex -1/λ_R, where λ_ex is the excitation wavelength and λ_R is the Raman spectrum wavelength. The pump wavelength used in the system described in this manuscript is occurring at 785 nm. Therefore, a Raman Shift of zero corresponds to the pump wavelength.</p

Imaging device and system.

<p>(a) Photographs of the components of the distal end of the device adjacent to a quarter (diameter = 24 mm) for scale. All the components shown, less the motor, were custom designed and fabricated for this device. (b) Close-up photograph of the distal end of the fully functional device. The fiber bundle was enclosed and sealed within a flexible extrusion sheath. The window was placed between the scan mirror and the tissue in order to seal the inner mechanisms of the device from fluids in the surrounding environment. The use of a toroidal mirror compensates for beam distortion from the curvature of the glass window in order to maintain a collimated beam. Utilization of a 50-degree inclination angle of the toroidal mirror effectively eliminates back reflections from the window into the fiber bundle detector. (c) System overview. A continuous wave (CW) laser at 785 nm was used and the Raman-scattered light is collected through the multi-mode fibers of the fiber bundle. At the proximal end of the fiber bundle, the multimode fibers are arranged into a vertical array for efficient coupling to the spectrometer. A long-pass filter at the entrance of the spectrometer filters out the illumination light. A function generator signal controls a motor control board to finely tune the rotational speed of the motor to the desired speed of 1 rev/s. (d) Photograph of the completed fully functional system.</p

Hollow lumen phantom multiplexing study.

<p>(a) Photograph of the paper phantom laid flat. Each letter and the spot beneath was pipetted on to paper using different SERS nanoparticle flavors (‘S’ = S493,‘P’ = S440, ‘E’ = S482, ‘C’ = S420, ‘T’ = S481, ‘R’ = S421). The ‘A’ and spot below were composed of an equal mixture of all six flavors at one-fifth the concentration; thus appearing dimmer than the other letters. The spots under each letter were below 1 mm in diameter, which is less than the size detectable with white-light endoscopy. (b) Photograph of the phantom with a radius set to 25 mm to mimic the average human colon radius. (c) Image of signal intensities of S493, S440, S482, S420, S481, and S421 shown as 2-D images. (d) Cylindrical three-dimensional reconstruction of the data acquired with the device showing a 5-cm segment of the phantom lumen. (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0123185#pone.0123185.s002" target="_blank">S2 Video</a>). There are a total of 5,000 pixels (50 rev x 100 pix/rev) acquired, which was obtained in a period of 50 seconds (1 rev/s). Each of the SERS flavors was assigned a specific color.</p

<i>In vivo</i> swine endoscopy model multiplexing study.

<p>A comparison of images after stepwise injections of a SERS nanoparticle cocktail. Using an endoscope, the injection was made into the esophageal mucosal layer of a fresh intact postmortem pig. The esophagus was then scanned using our device. (a-c) Cylindrical three-dimensional reconstruction of ratiometric signal intensities of S493, S440, and S420 from the stepwise-mixture injection site. A total of 8,000 pixels (80 rev x 100 pix/rev) were acquired in a period 80 seconds (1 rev/s). (a) Ratiometric signal intensity of S493. (b) Ratiometric signal intensity of S440. (c) Ratiometric signal intensity of S420. (d) The center values of each bar in the bar graph are the average of ratiometric values for each of the respective SERS flavors where the value is non-zero (<i>n</i> = 123 for S440 equimolar and S420 equimolar, and <i>n</i> = 128 for S440 step-wise and S420 step-wise). The error bars are standard errors of the mean. (e) Cylindrical three-dimensional ratiometric image of S420 (from (c)) superimposed onto the white-light endoscope image of the esophagus. The device can be seen in the upper left corner with the scan mirror and window.</p